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Candidate taste receptors in Drosophila
journal contributionposted on 2023-05-20, 02:51 authored by Clyne, PJ, Coral WarrCoral Warr, Carlson, JR
Little is known about the molecular mechanisms of taste perception in animals, particularly the initial events of taste signaling. A large and diverse family of seven transmembrane domain proteins was identified from the Drosophila genome database with a computer algorithm that identifies proteins on the basis of structure. Eighteen of 19 genes examined were expressed in the Drosophila labellum, a gustatory organ of the proboscis. Expression was not detected in a variety of other tissues. The genes were not expressed in the labellum of a Drosophila mutant, pox-neuro 70, in which taste neurons are eliminated. Tissue specificity of expression of these genes, along with their structural similarity, supports the possibility that the family encodes a large and divergent family of taste receptors.
Department/SchoolTasmanian School of Medicine
PublisherAmer Assoc Advancement Science
Place of publication1200 New York Ave, Nw, Washington, USA, Dc, 20005