File(s) under permanent embargo
Capsaicin and Zinc Signalling Pathways as Promising Targets for Managing Insulin Resistance and Type 2 Diabetes
journal contributionposted on 2023-05-21, 17:28 authored by Vahidi Ferdowsi, P, Kiran AhujaKiran Ahuja, Jeffrey BeckettJeffrey Beckett, Stephen MyersStephen Myers
The global burden of type 2 diabetes (T2DM) has led to significant interest in finding novel and effective therapeutic targets for this chronic disorder. Bioactive food components have effectively improved abnormal glucose metabolism associated with this disease. Capsaicin and zinc are food components that have shown the potential to improve glucose metabolism by activating signalling events in the target cells. Capsaicin and zinc stimulate glucose uptake through the activation of distinct pathways (AMPK and AKT, respectively); however, calcium signal transduction seems to be the common pathway between the two. The investigation of molecular pathways that are activated by capsaicin and zinc has the potential to lead to the discovery of new therapeutic targets for T2DM. Therefore, this literature review aims to provide a summary of the main signalling pathways triggered by capsaicin and zinc in glucose metabolism.
Department/SchoolSchool of Health Sciences
PublisherMolecular Diversity Preservation International
Place of publicationMatthaeusstrasse 11, Basel, Switzerland, Ch-4057