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Cellular and molecular mechanisms of vitamin D in food allergy

journal contribution
posted on 2023-05-22, 23:57 authored by Poole, A, Yong SongYong Song, Brown, H, Hart, PH, Zhang, GB
Food allergies are becoming increasingly prevalent, especially in young children. Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis. Links have been made between variations in sunlight exposure, latitude, birth season and vitamin D status with food allergy risk. Despite the heightened interest in vitamin D in food allergies, it remains unclear by which exact mechanism(s) it acts. An understanding of the roles vitamin D plays within the immune system at the cellular and genetic levels, as well as the interplay between the microbiome and vitamin D, will provide insight into the importance of the vitamin in food allergies. Here, we discuss the effect of vitamin D on immune cell maturation, differentiation and function; microbiome; genetic and epigenetic regulation (eg DNA methylation); and how these processes are implicated in food allergies.

History

Publication title

Journal of Cellular and Molecular Medicine

Volume

22

Issue

7

Pagination

3270-3277

ISSN

1582-1838

Department/School

Menzies Institute for Medical Research

Publisher

Carol Davila Univ Press

Place of publication

8 Eroilor Sanitari Blvd, Bucharesst, Romania, 76241

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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