Millennial-scale latitudinal shifts in the southern westerly winds (SWW) drive changes in Southern Ocean upwelling, leading to changes in atmospheric CO<sub>2</sub> levels, thereby affecting the global climate and carbon cycle. Our aim here is to understand whether century-scale shifts in the SWW also drive changes in atmospheric CO<sub>2</sub> content. We report new multiproxy lake sediment data from southwest Tasmania, Australia, that show centennial-scale changes in vegetation and fire activity over the past 2400 yr. We compare our results with existing data from southern South America and reveal synchronous and in-phase centennial-scale trends in vegetation and fire activity between southwest Tasmania and southern South America over the past 2400 yr. Interannual to centennial-scale rainfall anomalies and fire activity in both these regions are significantly correlated with shifts in the SWW associated with the Southern Annular Mode (SAM; atmospheric variability of the Southern Hemisphere). Thus, we interpret the centennial-scale trends we have identified as reflecting century-scale SAM-like shifts in the SWW over the past 2400 yr. We identify covariance between our inferred century-scale shifts in the SWW and Antarctic ice core CO<sub>2</sub> values, demonstrating that the SWW-CO<sub>2</sub> relationship operating at a millennial scale also operates at a centennial scale through the past 2400 yr. Our results indicate a possible westerly-driven modulation of recent increases in global atmospheric CO<sub>2</sub> content that could potentially exacerbate current greenhouse gas–related warming.