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Changes in cystic fibrosis mortality in Australia, 1979-2005

journal contribution
posted on 2023-05-17, 12:09 authored by Reid, DW, Christopher BlizzardChristopher Blizzard, Shugg, DM, Ceri FlowersCeri Flowers, Cash, CE, Greville, HM
Objective: To assess mortality trends among people with cystic fibrosis (CF) in Australia. Design and setting: We augmented Australian summary data for deaths from CF registered during 1979-2005 with information from Australian transplant centres on lung transplantation among CF patients for 1989-2005 to allow us to follow trends in all "mortality events" (death or lung transplantation). Main outcome measure: Age at death or lung transplantation. Results: Between 1979 and 2005, the mean age at death increased from 12.2 years to 27.9 years for males and from 14.8 years to 25.3 years for females. Overall, female deaths in childhood (0-14 years) occurred at an age-standardised rate of 0.40 per 100 000 (95% Cl, 0.34-0.45) during 1979-2005, which exceeded the corresponding rate for males of 0.24 (95% CI, 0.20-0.28) per 100 000. Among 0-14-year-old boys, event rates declined markedly after 1989, but they declined later and more gradually for girls, with the result that the age-standardised rate for girls was 2.38 times that of boys during 1989-2005 (95% CI, 1.69-3.36). Conclusions: The pattern of CF mortality in Australia has changed substantially. Mortality rates continue to be higher for girls than for boys, but death in childhood has become uncommon. Survival has increased since 1979, but females continue to have reduced length of life.

History

Publication title

Medical Journal of Australia

Volume

195

Issue

7

Pagination

392-395

ISSN

0025-729X

Department/School

Menzies Institute for Medical Research

Publisher

Australasian Med Publ Co Ltd

Place of publication

Level 1, 76 Berry St, Sydney, Australia, Nsw, 2060

Rights statement

Copyright 2011 Australasian Medical Publishing Company

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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