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Characterization and regulation of tachykinin receptors in the nucleus tractus solitarius

journal contribution
posted on 2023-05-16, 12:42 authored by Mazzone, SB, Dominic GeraghtyDominic Geraghty
1. The characteristics, localization and regulation of tachykinin receptors in the rat nucleus tractus solitarius (NTS) involved in respiratory control were investigated using a combination of in vivo microinjection and in vitro autoradiographic techniques. 2. Microinjection of receptor-selective tachykinin agonists and antagonists into the NTS of urethane-anaesthetized rats suggests that stimulation of NK1 and NK3 receptors increases tidal volume, whereas NK2 and NK3 receptor activation produces a bradypnoea. 3. Depletion of NK1 receptors in the NTS due to either ageing or acute hypoxia correlates with a markedly reduced respiratory response to substance P. In contrast, chemical ablation of sensory neurons by neonatal capsaicin administration dramatically increases the respiratory response to a variety of NK1, NK2 and NK3 agonists. 4. These studies suggest that all three tachykinin receptors are present in the rat NTS and that these receptors are subject to both acute and chronic regulation.

History

Publication title

Clinical and Experimental Pharmacology and Physiology

Volume

27

Issue

11

Pagination

939-942

ISSN

0305-1870

Department/School

School of Health Sciences

Publisher

Blackwell Science Asia

Place of publication

Carlton

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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