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Characterization of latent and active forms of cartilage proteinases produced by normal immature rabbit articular-cartilage in tissue-culture
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posted on 2023-05-17, 08:19 authored by Cartwright, EC, Campbell, IK, Margaret BritzMargaret Britz, Sandy, JD, Lowther, DACultured tissue slices from normal immature rabbit articular cartilage released latent neutral metalâ€loproteinases into serumâ€free medium. On activation with 4â€aminophenylmercuric acetate, these metalloproteinases could degrade collagen, proteoglycan, and gelatin. Also produced were an acid proteinase with the properties of cathepsin D and an inhibitor of the neutral metalloproteinases. The appearance of both the proteinases and the inhibitor in the culture medium could be prevented by incubation of cultures with cycloheximide. The active and latent forms of the proteinases were characterized using Ultrogel AcA 54 chromatography. Copyright © 1983 American College of Rheumatology
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Publication title
Arthritis and RheumatismVolume
26Issue
8Pagination
984-993ISSN
0004-3591Department/School
College Office - College of Sciences and EngineeringPublisher
Wiley-LissPlace of publication
Div John Wiley & Sons Inc, 605 Third Ave, New York, USA, Ny, 10158-0012Repository Status
- Restricted
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