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Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: Synthesis of 3-pyrrolines and 2-alkylpyrroles
journal contribution
posted on 2023-05-17, 07:35 authored by You, HT, Grosse, AC, Howard, JK, Hyland, CJT, Just, J, Molesworth, PP, Jason SmithJason SmithThe partial reduction of pyrroles is not a common practice even though it offers a potential route to pyrroline building blocks, commonly used for synthesis. We have investigated the reduction of 2-acyl-N-sulfonylpyrroles and by varying the hydride source and solvent, achieved a chemoselective reduction, leading to 3-pyrrolines and alkyl pyrroles in high yield.
Funding
University of Tasmania
History
Publication title
Organic & Biomolecular ChemistryVolume
9Issue
10Pagination
3948-3953ISSN
1477-0520Department/School
School of Natural SciencesPublisher
Royal Society of ChemistryPlace of publication
Thomas Graham House, Science Park, Milton Rd, Cambridge, England, Cambs, Cb4 0WfRights statement
Copyright 2011 The Royal Society of ChemistryRepository Status
- Restricted