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Circadian biology and stroke

journal contribution
posted on 2023-05-21, 02:34 authored by Lo, EH, Albers, GW, Dichgans, M, Donnan, G, Esposito, E, Foster, R, David Howells, Huang, YG, Ji, X, Klerman, EB, Lee, S, Li, W, Liebeskind, DS, Lizasoain, I, Mandeville, ET, Moro, MA, Ning, M, Ray, D, Sakadzic, S, Saver, JL, Scheer, FAJL, Selim, M, Tiedt, S, Zhang, F, Buchan, AM
Circadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest that circadian biology may significantly affect the mechanisms of susceptibility, injury, recovery, and the response to therapy in stroke. In this review/perspective, we survey the accumulating literature and attempt to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke. Accounting for the complex and multifactorial effects of circadian rhythm may improve translational opportunities for stroke diagnostics and therapeutics.

History

Publication title

Stroke

Volume

52

Issue

6

Pagination

2180-2190

ISSN

0039-2499

Department/School

Tasmanian School of Medicine

Publisher

Lippincott Williams & Wilkins

Place of publication

United States

Repository Status

  • Restricted

Socio-economic Objectives

Treatment of human diseases and conditions

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