University Of Tasmania
144180-Cognitive deficits in Parkinsons disease.pdf (1.11 MB)
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Cognitive deficits in Parkinson’s disease: current perspectives

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journal contribution
posted on 2023-05-20, 23:05 authored by Cosgrove, J, Jane AltyJane Alty
Cognitive dysfunction is a common and significant non-motor symptom of Parkinson’s disease (PD). PD mild cognitive impairment (PD-MCI) is evident in approximately one-quarter of patients at the time of PD diagnosis, and half of PD patients have progressed to PD dementia (PDD) after 10 years. The transition to PDD from PD-MCI is not linear and may depend on the facets of cognition affected. Despite increased understanding of pathological, neurotransmitter and genetic drivers, there are no proven pharmacological treatments for PDMCI and those licensed for PDD are of modest benefit only. Biomarkers to predict those most at risk of developing PDD are under investigation and are likely to be essential so that early and individualized treatment can be provided.


Publication title

Journal of Parkinsonism and Restless Legs Syndrome








Wicking Dementia Research Education Centre


Dove Medical Press Ltd.(DovePress)

Place of publication

New Zealand

Rights statement

Copyright 2018 Cosgrove and Alty. Licensed under Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)

Repository Status

  • Open

Socio-economic Objectives

Diagnosis of human diseases and conditions