posted on 2023-05-20, 23:05authored byCosgrove, J, Jane AltyJane Alty, Jamieson, S
Cognitive impairment is a significant non-motor symptom of Parkinson's disease (PD). Longitudinal cohort studies have demonstrated that approximately 50% of those with PD develop dementia after 10 years, increasing to over 80% after 20 years. Deficits in cognition can be identified at the time of PD diagnosis in some patients and this mild cognitive impairment (PD-MCI) has been studied extensively over the last decade. Although PD-MCI is a risk factor for developing Parkinson's disease dementia there is evidence to suggest that PD-MCI might consist of distinct subtypes with different pathophysiologies and prognoses. The major pathological correlate of Parkinson's disease dementia is Lewy body deposition in the limbic system and neocortex although Alzheimer's related pathology is also an important contributor. Pathological damage causes alteration to neurotransmitter systems within the brain, producing behavioural change. Management of cognitive impairment in PD requires a multidisciplinary approach and accurate communication with patients and relatives is essential.
History
Publication title
Postgraduate Medical Journal
Volume
91
Issue
1074
Pagination
212-220
ISSN
0032-5473
Department/School
Wicking Dementia Research Education Centre
Publisher
B M J Publishing Group
Place of publication
British Med Assoc House, Tavistock Square, London, England, Wc1H 9Jr
Repository Status
Restricted
Socio-economic Objectives
Diagnosis of human diseases and conditions; Health related to ageing