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Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma

journal contribution
posted on 2023-05-17, 05:00 authored by Thorleifsson, G, Walters, GB, Alexander HewittAlexander Hewitt, Masson, G, Helgason, A, DeWan, A, Sigurdsson, A, Jonasdottir, A, Gudjonsson, SA, Magnusson, KP, Stefansson, H, Lam, DSC, Tam, POS, Gudmundsdottir, GJ, Southgate, L, Kathryn BurdonKathryn Burdon, Gottfredsdottir, MS, Aldred, MA, Mitchell, P, St Clair, D, Collier, DA, Tang, N, Sveinsson, O, Macgregor, S, Martin, NG, Cree, AJ, Gibson, J, MacLeod, A, Jacob, A, Ennis, S, Young, TL, Chan, JCN, Karwatowski, WSS, Hammond, CJ, Thordarson, K, Zhang, M, Wadelius, C, Lotery, AJ, Trembath, RC, Pang, CP, Hoh, J, Craig, JE, Kong, A, David MackeyDavid Mackey, Jonasson, F, Thorsteinsdottir, U, Stefansson, K
We conducted a genome-wide association study for primary open-angle glaucoma (POAG) in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a common sequence variant at 7q31 (rs4236601[A], odds ratio (OR) = 1.36, P = 5.0 '- 10 ĝ̂'10). We then replicated the association in sample sets of 2,175 POAG cases and 2,064 controls from Sweden, the UK and Australia (combined OR = 1.18, P = 0.0015) and in 299 POAG cases and 580 unaffected controls from Hong Kong and Shantou, China (combined OR = 5.42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG. © 2010 Nature America, Inc. All rights reserved.


Publication title

Nature Genetics










Menzies Institute for Medical Research


Nature Publishing Group

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345 Park Ave South, New York, USA, Ny, 10010-1707

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