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Comparison of 6-month outcomes of COVID-19 vs Non-COVID-19 survivors of critical illness

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posted on 2023-05-21, 06:48 authored by Hodgson, CL, Higgins, AM, Bailey, MJ, Mather, AM, Beach, L, Bellomo, R, Bissett, B, Ianthe BodenIanthe Boden, Bradley, S, Burrell, A, Cooper, DJ, Fulcher, BJ, Haines, KJ, Hodgson, IT, Hopkins, J, Jones, AYM, Lane, S, Lawrence, D, van der Lee, L, Liacos, J, Linke, NJ, Marques Gomes, L, Nickels, M, Ntoumenopoulos, G, Myles, PS, Patman, S, Paton, M, Pound, G, Rai, S, Rix, A, Rollinson, TC, Tipping, CJ, Thomas, P, Trapani, T, Udy, AA, Whitehead, C, Anderson, S, Neto, AS

Rationale: The outcomes of survivors of critical illness due to coronavirus disease (COVID-19) compared with non-COVID-19 are yet to be established. Objectives: We aimed to investigate new disability at 6 months in mechanically ventilated patients admitted to Australian ICUs with COVID-19 compared with non-COVID-19.

Methods:We included critically ill patients with COVID-19 and non-COVID-19 from two prospective observational studies. Patients were eligible if they were adult (age ⩾ 8 yr) and received ⩾24 hours of mechanical ventilation. In addition, patients with COVID-19 were eligible with a positive laboratory PCR test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Measurements and Main Results: Demographic, intervention, and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0. Between March 6, 2020, and April 21, 2021, 120 critically ill patients with COVID-19, and between August 2017 and January 2019, 199 critically ill patients without COVID-19, fulfilled the inclusion criteria. Patients with COVID-19 were older (median [interquartile range], 62 [55-71] vs. 58 [44-69] yr; P = 0.019) with a lower Acute Physiology and Chronic Health Evaluation II score (17 [13-20] vs. 19 [15-23]; P = 0.011). Although duration of ventilation was longer in patients with COVID-19 than in those without COVID-19 (12 [5-19] vs. 4.8 [2.3-8.8] d; P < 0.001), 180-day mortality was similar between the groups (39/120 [32.5%] vs. 70/199 [35.2%]; P = 0.715). The incidence of death or new disability at 180 days was similar (58/93 [62.4%] vs. 99/150 [66/0%]; P = 0.583).

Conclusions: At 6 months, there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared with non-COVID-19. Clinical trial registered with (NCT04401254).


Publication title

American Journal of Respiratory and Critical Care Medicine










School of Health Sciences


Amer Thoracic Soc

Place of publication

1740 Broadway, New York, USA, Ny, 10019-4374

Rights statement

©2022 American Thoracic Society. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0.(CC BY-NC-ND 4.0)

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified; Health surveillance