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Counter-flow electrokinetic supercharging for the determination of non-steroidal anti-inflammatory drugs in water samples

journal contribution
posted on 2023-05-16, 23:25 authored by Dawod, M, Michael BreadmoreMichael Breadmore, Rosanne Guijt, Paul HaddadPaul Haddad
Electrokinetic supercharging (EKS) has been used in the last few years as a powerful tool for separation and on-line preconcentration of different types of analytes. We have developed a valuable modification for EKS system, namely counter-flow EKS (CF-EKS) and applied it for the separation and on-line preconcentration of seven non-steroidal anti-inflammatory drugs (NSAIDs) in water samples. In CF-EKS, a hydrodynamic counter-flow is applied during electrokinetic injection of the analytes within the EKS system. This counter-flow minimises the introduction of the sample matrix into the capillary, allowing longer injections to be performed. Careful choice of the optimum counter-flow as well as the optimum injection voltage allowed the sensitivity to be enhanced by 11,800-fold, giving limits of detection (LODs) of 10.7–47.0 ng/L for the selected NSAIDs. The developed method was validated and then applied for the determination of the studied NSAIDs in drinking water as well as wastewater samples from Hobart city.

History

Publication title

Journal of Chromatography A

Volume

1216

Issue

15

Pagination

3380-3386

ISSN

0021-9673

Department/School

School of Natural Sciences

Publisher

Elsevier

Place of publication

Amsterdam

Rights statement

The definitive version is available at http://www.sciencedirect.com

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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