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Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound

journal contribution
posted on 2023-05-19, 07:30 authored by Blackwood, SJ, Renee RossRenee Ross, Bradley, EA, Michelle Keske, Stephen RichardsStephen Richards, Stephen RattiganStephen Rattigan
Most methods of assessing flowmotion (rhythmic oscillation of blood flow through tissue) are limited to small sections of tissue and are invasive in tissues other than skin. To overcome these limitations, we adapted the contrast-enhanced ultrasound (CEUS) technique to assess microvascular flowmotion throughout a large region of tissue, in a non-invasive manner and in real time. Skeletal muscle flowmotion was assessed in anaesthetised Sprague Dawley rats, using CEUS and laser Doppler flowmetry (LDF) for comparison. Wavelet transformation of CEUS and LDF data was used to quantify flowmotion. The α-adrenoceptor antagonist phentolamine was infused to predictably blunt the neurogenic component of flowmotion. Both techniques identified similar flowmotion patterns, validating the use of CEUS to assess flowmotion. This study demonstrates for the first time that the novel technique of CEUS can be adapted for determination of skeletal muscle flowmotion in large regions of skeletal muscle.

History

Publication title

Ultrasound in Medicine and Biology

Volume

43

Issue

9

Pagination

2013-2023

ISSN

0301-5629

Department/School

Menzies Institute for Medical Research

Publisher

Elsevier Science Inc

Place of publication

360 Park Ave South, New York, USA, Ny, 10010-1710

Rights statement

© 2017 World Federation for Ultrasound in Medicine & Biology

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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