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Diabetes therapies for dementia
Recent Findings: Results from basic laboratory research support the potential for commonly-used medications for T2D, including those with direct glucose-lowering properties, to have a beneficial effect on brain health. However, human studies have been mostly observational in nature and report conflicting results. Preliminary data suggest that intranasal insulin, metformin, and GLP-1 agonists show promise for dementia, but confirmatory evidence for their benefit in dementia is still lacking.
Summary: Current evidence does not support the repurposing of T2D medications for dementia risk reduction or management. Research in the field of T2D and dementia is active, and further data are required before definitive conclusions can be drawn.
Publication titleCurrent Neurology and Neuroscience Reports
Department/SchoolMenzies Institute for Medical Research
Place of publicationUnited States
Rights statementCopyright 2019 Springer Science-Business Media, LLC, part of Springer Nature