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Direct enantioselective HPLC monitoring of lipase-catalyzed kinetic resolution of flurbiprofen
journal contribution
posted on 2023-05-17, 00:37 authored by Ghanem, AThe solvent versatility of Chiralpak IB, a 3,5-dimethylphenylcarbamate derivative of cellulose-based chiral stationary phase, is demonstrated in the direct enantioselective HPLC monitoring of lipase-catalyzed kinetic resolution of flurbiprofen in nonstandard HPLC organic solvents. Nonstandard HPLC organic solvents were used as the reaction media for the lipase-catalysis and in mean time as diluent to dissolve the difficult to dissolve enzyme substrate (the acid) and as eluent for the simultaneous enantioselective HPLC baseline separation of both substrate and product in one run without any further derivatization.
Funding
Pfizer
History
Publication title
ChiralityVolume
22Issue
6Pagination
597-603ISSN
0899-0042Department/School
School of Natural SciencesPublisher
Wiley-BlackwellPlace of publication
Malden USARights statement
The definitive published version is available online at: http://www.interscience.wiley.comRepository Status
- Restricted