University of Tasmania
Browse

File(s) not publicly available

Disease Severity of Familial Glaucoma Compared With Sporadic Glaucoma

journal contribution
posted on 2023-05-16, 18:01 authored by Wu, J, Alexander HewittAlexander Hewitt, Green, CM, Ring, M, McCartney, PJ, Craig, JE, David MackeyDavid Mackey
Objective: To determine whether there is a difference in disease severity between familial and sporadic primary open-angle glaucoma (POAG). Methods: A cross-sectional study design compared the distribution of Glaucoma Inheritance Study in Tasmania (GIST) severity scores of patients with genealogically confirmed familial POAG and those with sporadic POAG. The GIST severity scores provide a combined weighting of glaucoma severity based on findings from visual field defects and optic disc analysis, with and without intraocular pressure. A Poisson regression analysis, t test, and χ 2 tests were performed. Results: One thousand twelve (59.5%) of 1700 subjects had familial glaucoma. The mean ± SD age at examination was greater in the sporadic POAG group compared with the familial group (72.6 ± 10.3 years vs 70.6 ± 12.6 years; P = .001). The family group was significantly younger at diagnosis than the sporadic group (mean ± SD, 61.4 ± 13.0 years vs 64.0 ± 12.6 years; P<.001). The GIST severity scores were significantly skewed toward greater disease severity in the familial group compared with the sporadic group (P<.001). Conclusion: Identifying individuals at risk of severe POAG will be more successful if screening programs are developed with appropriate weighting toward those with a positive family history of the disease. ©2006 American Medical Association. All rights reserved.

History

Publication title

Archives of Ophthalmology

Volume

124

Issue

7

Pagination

950-954

ISSN

0003-9950

Department/School

Tasmanian School of Medicine

Publisher

AMER MEDICAL ASSOC,

Place of publication

Chicago USA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC