University Of Tasmania
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Do microglia default on network maintenance in Alzheimer's disease?

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journal contribution
posted on 2023-05-18, 18:04 authored by Katherine SouthamKatherine Southam, Vincent, AJ, David SmallDavid Small
Although the cause of Alzheimer's disease (AD) remains unknown, a number of new findings suggest that the immune system may play a critical role in the early stages of the disease. Genome-wide association studies have identified a wide array of risk-associated genes for AD, many of which are associated with abnormal functioning of immune cells. Microglia are the brain's immune cells. They play an important role in maintaining the brain's extracellular environment, including clearance of aggregated proteins such as amyloid-β (Aβ). Recent studies suggest that microglia play a more active role in the brain than initially considered. Specifically, microglia provide trophic support to neurons and also regulate synapses. Microglial regulation of neuronal activity may have important consequences for AD. In this article we review the function of microglia in AD and examine the possible relationship between microglial dysfunction and network abnormalities, which occur very early in disease pathogenesis.


Dementia Australia Research Foundation Ltd


Publication title

Journal of Alzheimer's Disease








Menzies Institute for Medical Research


IOS Press

Place of publication


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Copyright 2016 – IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License.

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  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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