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Duration of posttraumatic stress disorder predicts hippocampal grey matter loss

journal contribution
posted on 2023-05-17, 07:11 authored by Kim FelminghamKim Felmingham, Williams, LM, Whitford, TJ, Falconer, E, Kemp, AH, Peduto, A, Bryant, RA
To examine the impact of environmental stress on grey matter volume in posttraumatic stress disorder (PTSD), we investigated the relationship between duration of PTSD and grey matter volume of hippocampus and anterior cingulate cortex. Twenty-one participants with PTSD and 17 trauma-exposed controls, matched for age and sex and with no history of substance dependence, underwent a T1-weighted structural MRI scan and voxel-based morphometry was employed. After controlling for age, depression and whole-brain volume, analysis of covariance revealed significant reductions in hippocampus and rostral anterior cingulate cortex in PTSD, and there was a significant negative correlation between right hippocampal volume and PTSD duration. This pattern suggests that prolonged PTSD may have cumulative adverse effects on hippocampal volume, highlighting the potential role of genetic–environmental interactions.

History

Publication title

Neuroreport

Volume

20

Issue

16

Pagination

1402-1406

ISSN

0959-4965

Department/School

School of Psychological Sciences

Publisher

Lippincott Williams & Wilkins

Place of publication

530 Walnut St, Philadelphia, USA, Pa, 19106-3621

Rights statement

Copyright © 2009 Lippincott Williams & Wilkins

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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