File(s) under permanent embargo
EMT signaling: potential contribution of CRISPR/Cas gene editing
journal contributionposted on 2023-05-22, 23:58 authored by Mohammadinejad, R, Biagioni, A, Arunkumar, G, Shapiro, R, Chang, KC, Mohammed SedeeqMohammed Sedeeq, Taiyab, A, Hashemabadi, M, Pardakhty, A, Mandegary, A, Thiery, JP, Aref, AR, Iman AzimiIman Azimi
Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fbrosis, cancer metastasis and drug resistance. In recent years, the ability to edit the genome using the clustered regularly interspaced palindromic repeats (CRISPR) and associated protein (Cas) system has greatly contributed to identify or validate critical genes in pathway signaling. This review delineates the complex EMT networks and discusses recent studies that have used CRISPR/Cas technology to further advance our understanding of the EMT process.
Publication titleCellular and Molecular Life Sciences
Department/SchoolSchool of Pharmacy and Pharmacology
PublisherBirkhauser Verlag Ag
Place of publicationViadukstrasse 40-44, Po Box 133, Basel, Switzerland, Ch-4010