University Of Tasmania
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Effect of insulin-induced lipodystrophy on glycemic control among children and adolescents with diabetes in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

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journal contribution
posted on 2023-05-21, 01:36 authored by Tsadik, AG, Tesfay Mehari Atey, Nedi, T, Fantahun, B, Feyissa, M

Background: Lipodystrophy is one of the clinical complications of insulin injection that affects insulin absorption and leads to poor glycemic control.

Objective: To assess insulin-induced lipodystrophy and glycemic control.

Methods: A cross sectional study was done on 176 diabetic children and adolescents who inject insulin for a minimum of one year. First, anthropometric and clinical characteristics of the patients were recorded in questionnaire, and then observation and palpation techniques were used in assessing lipodystrophy.

Result: Out of the total 176 participants, 103 (58.5%) had insulin-induced lipodystrophy, of them 100 (97.1%) had lipohypertrophy and 3 (2.9%) had lipoatrophy. Being younger, failure to rotate the injection site every week and multiple reuse of insulin syringe had significant influence in development of insulin-induced lipohypertrophy. Lipohypertrophy in turn was associated with the use of higher dose of insulin and nonoptimal glycemic control.

Conclusion: Findings of this study revealed that in spite of using recombinant human insulin, the magnitude of the lipohypertrophy still remained high. Therefore, a routine workup of insulin-injecting patients for such complication is necessary, especially in the individuals who have a nonoptimal glycemic control.


Publication title

Journal of Diabetes Research






School of Pharmacy and Pharmacology


Hindawi Limited

Place of publication

United Kingdom

Rights statement

Copyright 2018 Afewerki Gebremeskel Tsadik et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

Repository Status

  • Open

Socio-economic Objectives

Human pharmaceutical treatments