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Effects of Indoor, Outdoor, and Personal Exposure to Particulate Air Pollution on Cardiovascular Physiology and Systemic Mediators in Seniors
Objective: To investigate the associations between exposure to particulate air pollution and changes in cardiovascular function and plasma mediators in seniors.
Methods: We monitored daily indoor and outdoor black carbon and particulate matter <=2.5um (PM2.5) and personal PM2.5 repeatedly for 28 nonsmoking seniors. We then measured their blood pressure, heart rate, and brachial artery function, and determined plasma mediators of inflammation, vascular function, and oxidative stress. We tested associations using mixed-effects models.
Results: Increases in black carbon and PM2.5 were associated with increases in blood pressure, heart rate, endothelin-1, vascular endothelial growth factor, and oxidative stress marker thiobarbituric acid reactive substances, and a decrease in brachial artery diameter (P<0.05).
Conclusion: Daily exposure to particulate pollution, likely trafficrelated, may result in adverse effects on cardiovascular function and blood mediators that modulate vascular system in seniors.
History
Publication title
Journal of Occupational and Environmental MedicineVolume
51Issue
9Pagination
1088-10098ISSN
1076-2752Department/School
Menzies Institute for Medical ResearchPublisher
Lippincott Williams & WilkinsPlace of publication
530 Walnut St, Philadelphia, USA, Pa, 19106-3621Rights statement
Copyright 2009 The American College of Occupational and Environmental MedicineRepository Status
- Restricted