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Effects of Procainamide on Transmural Ventricular Repolarisation
journal contributionposted on 2023-05-16, 13:37 authored by Wang, L, Yong, AC, David KilpatrickDavid Kilpatrick
To investigate the pharmacological effect of procainamide on transmural ventricular repolarisation in normal heart, the transmural activation-recovery intervals (ARI) and their responses to procainamide (20 mg/min i.v. for 20 min) were studied in 6 open-chest, pentobarbitone-anaesthetised sheep. ARI was measured from the unipolar ECGs acquired with 4 plunge needles inserted into the basal and apical parts of the left ventricular wall. During sinus rhythm (cycle length 500-700 ms), there was no significant difference in the pooled ARI between the epicardium (266.0 Â± 30.5 ms), midmyocardium (265.0 Â± 28.9 ms) and endocardium (265.7 Â± 28.1 ms) (p>0.05). Procainamide prolonged ARI in all myocardial layers. The pooled ARI prolongation from the epicardium, midmyocardium and endocardium of the 6 animals was 66.8 Â± 18.3, 70.3 Â± 14.7 and 65.3 Â± 15.7 ms (p < 0.05), respectively. In conclusion, sodium channel blocker procainamide results in a similar repolarisation prolongation in the left ventricular epicardium, midmyocardium and endocardium of a healthy heart.
Publication titleCardiovascular Drugs and Therapy
Department/SchoolTasmanian School of Medicine
PublisherKluwer Academic Publ
Place of publicationNetherlands