Effects of aldosterone on forearm vasculature in treated chronic heart failure
journal contribution
posted on 2023-05-17, 01:38authored byGunaruwan, P, Schmitt, M, James SharmanJames Sharman, Lee, L, Struthers, A, Frenneaux, M
The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.
History
Publication title
The American Journal of Cardiology
Volume
95
Pagination
412-414
ISSN
0002-9149
Department/School
Menzies Institute for Medical Research
Publisher
Excerpta Medica Inc
Place of publication
650 Avenue Of The Americas, New York, USA, Ny, 10011