University of Tasmania
Browse
DOCUMENT
Effects of ambient coarse fine and UFP and their biological constituents on systemic biomarkers - EHP 2015.pdf (609.55 kB)
DOCUMENT
Effects of ambient coarse fine and UFP and their biological constituents on systemic biomarkers - EHP 2015 SI.pdf (268.2 kB)
1/0
2 files

Effects of ambient coarse, fine, and ultrafine particles and their biological constituents on systemic biomarkers: a controlled human exposure study

journal contribution
posted on 2023-05-18, 10:54 authored by Liu, L, Urch, B, Poon, R, Szyszkowicz, M, Speck, M, Gold, DR, Amanda WheelerAmanda Wheeler, Scott, JA, Brook, JR, Thorne, PS, Silverman, FS
BACKGROUND: Ambient coarse, fine, and ultrafine particles have been associated with mortality and morbidity. Few studies have compared how various particle size fractions affect systemic biomarkers.

OBJECTIVES: We examined changes of blood and urinary biomarkers following exposures to three particle sizes.

METHODS: Fifty healthy nonsmoking volunteers, mean age of 28 years, were exposed to coarse (2.5-10 μm; mean, 213 μg/m3) and fine (0.15-2.5 μm; mean, 238 μg/m3) concentrated ambient particles (CAPs), and filtered ambient and/or medical air. Twenty-five participants were exposed to ultrafine CAP (< 0.3 μm; mean, 136 μg/m3) and filtered medical air. Exposures lasted 130 min, separated by ≥ 2 weeks. Blood/urine samples were collected preexposure and 1 hr and 21 hr postexposure to determine blood interleukin-6 and C-reactive protein (inflammation), endothelin-1 and vascular endothelial growth factor (VEGF; vascular mediators), and malondialdehyde (lipid peroxidation); as well as urinary VEGF, 8-hydroxy-deoxy-guanosine (DNA oxidation), and malondialdehyde. Mixed-model regressions assessed pre- and postexposure differences.

RESULTS: One hour postexposure, for every 100-μg/m3 increase, coarse CAP was associated with increased blood VEGF (2.41 pg/mL; 95% CI: 0.41, 4.40) in models adjusted for O3, fine CAP with increased urinary malondialdehyde in single- (0.31 nmol/mg creatinine; 95% CI: 0.02, 0.60) and two-pollutant models, and ultrafine CAP with increased urinary 8-hydroxydeoxyguanosine in single- (0.69 ng/mg creatinine; 95% CI: 0.09, 1.29) and two-pollutant models, lasting < 21 hr. Endotoxin was significantly associated with biomarker changes similar to those found with CAPs.

CONCLUSIONS: Ambient particles with various sizes/constituents may influence systemic biomarkers differently. Endotoxin in ambient particles may contribute to vascular mediator changes and oxidative stress.

History

Publication title

Environmental Health Perspectives

Volume

123

Issue

6

Pagination

534-540

ISSN

0091-6765

Department/School

Menzies Institute for Medical Research

Publisher

Us Dept Health Human Sciences Public Health Science

Place of publication

Natl Inst Health, Natl Inst Environmental Health Sciences, Po Box 12233, Res Triangle Pk, USA, Nc, 27709-2233

Rights statement

Reproduced with permission from Environmental Health Perspectives

Repository Status

  • Open

Socio-economic Objectives

Public health (excl. specific population health) not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC