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Effects of vaccinia virus-expressed interleukin 2 on the immune system of sublethally irradiated mice
journal contribution
posted on 2023-05-20, 21:06 authored by Andrew, ME, Gunasegaran KarupiahGunasegaran Karupiah, Boyle, DB, Blanden, RV, Mullbacher, A, Ramshaw, IA, Coupar, BEVaccinia virus that expressed interleukin 2 (IL 2) was cleared from immunodeficient irradiated mice more efficiently than virus that did not express interleukin 2. These results extend the previously observed protection from nude mice to another model of immunodeficiency. No antibody or cytotoxic T lymphocyte response could be detected in sublethally irradiated mice that had been inoculated with IL 2-expressing vaccinia virus, but levels of splenic natural killer cell activity were elevated. Sublethally irradiated mice that had recovered from IL 2-plus hemagglutinin-expressing vaccinia virus were partially protected against both influenza virus and vaccinia virus. These results indicate that vaccinia virus-expressed IL 2 mediates clearance of primary viral infection via a mechanism that does not involve antibody or cytotoxic T lymphocytes. They also indicate that inclusion of lymphokine genes in live recombinant viral vaccine vectors may increase vaccine safety.
History
Publication title
Microbial PathogenesisVolume
10Issue
5Pagination
363-71ISSN
0882-4010Department/School
Tasmanian School of MedicinePublisher
Academic PressPlace of publication
United KingdomRights statement
© 1991 Academic Press LimitedRepository Status
- Restricted