Version 2 2023-06-23, 10:53Version 2 2023-06-23, 10:53
Version 1 2023-05-25, 23:13Version 1 2023-05-25, 23:13
journal contribution
posted on 2023-06-23, 10:53authored byMJ Adams, C Ward, J Thom, A Bianchi, E Perrin, D Coughlan, M Smith
Technology in hemostasis laboratories has evolved enormously during the last 30 years. Although many scientists and clinicians will remember the traditional tilt-tube techniques to screen for coagulation abnormalities and to monitor anticoagulant therapy, the hemostasis laboratory today uses a variety of modern technologies. These include flow cytometry, chromogenic assays, molecular typing (e.g., polymerase chain reaction), immunologic assays (e.g., enzyme-linked immunosorbent assays), functional assays of specific coagulation proteins, and platelet function analyzers. Although these advances in technology have resulted in greater capability, productivity, sensitivity, specificity, and ultimately, improvement in the clinical care of patients, controversies and limitations remain. This article highlights new and emerging technologies in hemostasis and discusses whether they have improved or are likely to improve laboratory diagnostics by specifically addressing the following: (1) Can new technologies help predict likelihood of thrombosis recurrence? (2) Has an understanding of the role of A Disintegrin-like And Metalloprotease with Thrombo Spondin type 1 motifs (ADAMTS13) in microangiopathy resulted in improved diagnostic methods for this disorder? (3) Does thrombelastography allow better definition of bleeding risk than conventional hemostasis assays, especially in settings of acute hemostatic pathology?
History
Publication title
Seminars in Thrombosis and Hemostasis
Volume
33
Issue
3
Article number
3
Number
3
Pagination
226-234
ISSN
0094-6176
Department/School
Health Sciences
Publisher
Thieme
Publication status
Published
Rights statement
Copyright 2007, Georg Thieme Verlag. Definitive version is available online at http://www.thieme-connect.de/ejournals/toc/sth/6268