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Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus

journal contribution
posted on 2023-05-20, 21:02 authored by Mahalingam, S, Gunasegaran KarupiahGunasegaran Karupiah, Takeda, K, Akira, S, Matthaei, KI, Foster, PS
We inoculated BALByc mice deficient in STAT6 (STAT62/2) and their wild-type (wt) littermates (STAT61/1) with the natural mouse pathogen, ectromelia virus (EV). STAT62/2 mice exhibited increased resistance to generalized infection with EV when compared with STAT61/1 mice. In the spleens and lymph nodes of STAT62/2 mice, T helper 1 (Th1) cytokines were induced at earlier time points and at higher levels postinfection when compared with those in STAT61/1 mice. Elevated levels of NO were evident in plasma and splenocyte cultures of EV-infected STAT62/2 mice in comparison with STAT61/1 mice. The induction of high levels of Th1 cytokines in the mutant mice correlated with a strong natural killer cell response. We demonstrate in genetically susceptible BALByc mice that the STAT6 locus is critical for progression of EV infection. Furthermore, in the absence of this transcription factor, the immune system defaults toward a protective Th1-like response, conferring pronounced resistance to EV infection and disease progression.

History

Publication title

National Academy of Sciences of The United States of America. Proceedings

Volume

98

Issue

12

Pagination

6812-6817

ISSN

0027-8424

Department/School

Tasmanian School of Medicine

Publisher

Natl Acad Sciences

Place of publication

2101 Constitution Ave Nw, Washington, USA, Dc, 20418

Rights statement

Copyright 2001 the authors

Repository Status

  • Restricted

Socio-economic Objectives

Prevention of human diseases and conditions; Treatment of human diseases and conditions

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