Catamarans experience more types of global load than monohulls, these include pitch connecting moment, transverse bending moment, and split force. High-speed catamarans are widely used for passenger transportation but as the speed and size increase the severity of loads rises due to slam induced effects. In this study, full-scale CFD simulations are undertaken to investigate the loads acting on a 98m Incat wave-piercer catamaran (Hull 061) HSV2 Swift. Simulations are performed for conditions of a selected sea trial run in bow quartering seas at 20 knots forward speed undertaken by the Naval Surface Warfare Center, Carderock Division (NSWCCD), enabling comparisons and validation. In order to estimate internal global loads at different sections of the vessel, rigid body dynamics is applied based on the hydrodynamic and inertia forces. Those internal loads include longitudinal bending moment (LBM), pitch connecting moment (PCM), torsional moment (TorM), transverse bending moment (TBM), split force and prying moment. The estimated and measured global loads are also compared with design loads limits provided by DNV GL rules, and peak values of pitch and roll accelerations corresponding to each slam load are determined at the same wave height and wave period as the sea trial. The application of CFD to simulate sea trials runs in oblique seas is shown to provide a reliable estimation of slam induced loads for application in early design stages.