University Of Tasmania
BJMMR Evaluationg Markers of Oxidative Stress in Managing GDM in Iraq.pdf (309.45 kB)

Evaluating markers of oxidative stress in managing gestational diabetes mellitus: a cross sectional study in Iraq

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journal contribution
posted on 2023-05-18, 04:16 authored by Jamil, D, Al-Aubaidy, H, Al-Wasiti, E, Al Bayati, M

Aims: The objective of the present study was to evaluate the association of oxidative stress markers and antioxidants in gestational diabetes when compared to non-diabetic pregnant women.

Methodology: This is a cross-sectional study, conducted in Al-Husayniya Medical Centre, Baghdad, Iraq and included 73 participants attending the Maternal and Childhood Unit for the period between January 2008 and May 2010.

Results: Serum 8-Hydroxy-2-Deoxyguanosine was significantly greater in the gestational diabetes mellitus group compared to control group (57.2 ± 17.6ng/dl versus 19.8 ± 7.8ng/dl respectively, P < .05). The increase in 8-Hydroxy-2-Deoxyguanosine was associated with a significant elevation in serum total cholesterol and high density lipoprotein cholesterol and a significant reduction in serum superoxide dismutase in the gestational diabetes mellitus group compared to the control group at P < .05. A significant negative correlation was noted between 8-Hydroxy-2-Deoxyguanosine and superoxide dismutase among all the participants included in this study (r = 0.66 at P < .05).

Conclusions: The current study proves the importance of measuring markers of oxidative stress (expressed by serum 8-Hydroxy-2-Deoxyguanosine & serum lipids) and antioxidants (expressed by serum superoxide dismutase) in managing cases of gestational diabetes mellitus and provides a useful way of assessing the disease progression and/or remission in response to the treatment.


Publication title

British Journal of Medicine and Medical Research










Tasmanian School of Medicine


Sciencedomain International

Place of publication


Rights statement

Copyright 2014 Jamil et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Open

Socio-economic Objectives

Clinical health not elsewhere classified