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Evidence for a common genetic aetiology in high-risk families with multiple haematological malignancy subtypes

journal contribution
posted on 2023-05-17, 03:18 authored by Tegg, EM, Russell Thomson, Jim Stankovich, Annette BanksAnnette Banks, Ceri FlowersCeri Flowers, Rebekah McWhirterRebekah McWhirter, Panton, J, Piaszczyk, A, Bahlo, M, Marsden, KA, Raymond Lowenthal, Simon James FooteSimon James Foote, Joanne DickinsonJoanne Dickinson
A family history of a haematological malignancy (HM) is known to be a risk factor for HMs. However, collections of large families with multiple cases of varied disease types are relatively rare. We describe a collection of 12 families with dense aggregations of multiple HM subtypes. Cases were ascertained from a population based study conducted between 1972 and 1980 in Tasmania, Australia. Diagnoses were confirmed through review and re-examination of stored tissue, pathology reports, Tasmanian Cancer Registry and flow cytometry records. Family trees were generated and kinship coefficients were calculated for all pairs of affected individuals. 120 cases were found in these families. Cases diagnosed with chronic lymphocytic leukaemia (CLL) demonstrated the most significantly increased aggregation (P < 0Æ0001). There was also significant evidence that those individuals diagnosed at an older age (>53 years), did not aggregate together in families with disease that presented at an earlier age (<20 years) (P = 0Æ009).

History

Publication title

British Journal of Haematology

Volume

150

Issue

4

Pagination

456-462

ISSN

0007-1048

Department/School

Menzies Institute for Medical Research

Publisher

Blackwell Publishing Ltd

Place of publication

9600 Garsington Rd, Oxford, England, Oxon, Ox4 2Dg

Rights statement

The definitive published version is available online at: http://interscience.wiley.com

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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