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Frugier 2016 autophagy after stroke.pdf (2.29 MB)

Evidence for the recruitment of autophagic vesicles in human brain after stroke

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posted on 2023-05-19, 10:52 authored by Frugier, T, Taylor, JM, McLean, C, Nicole ByeNicole Bye, Beart, PM, Devenish, RJ, Crack, PJ
Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.

History

Publication title

Neurochemistry international

Volume

96

Pagination

62-68

ISSN

0197-0186

Department/School

School of Pharmacy and Pharmacology

Publisher

Pergamon-Elsevier Science Ltd

Place of publication

United Kingdom

Rights statement

Copyright 2016 Elsevier Ltd.

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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