University Of Tasmania

File(s) under permanent embargo

Evidence of heterogeneity by race/ethnicity in genetic determinants of QT interval

journal contribution
posted on 2023-05-20, 18:48 authored by Seyerle, AA, Young, AM, Jeff, JM, Phillip MeltonPhillip Melton, Jorgensen, NW, Lin, Y, Carty, CL, Deelman, E, Heckbert, SR, Hindorf, LA, Jackson, RD, Martin, LW, Okin, PM, Perez, MV, Psaty, BM, Soliman, EZ, Whitsel, EA, North, KE, Laston, S, Kooperberg, C, Avery, CL

Background: QT interval (QT) prolongation is an established risk factor for ventricular tachyarrhythmia and sudden cardiac death. Previous genome-wide association studies in populations of the European descent have identified multiple genetic loci that influence QT, but few have examined these loci in ethnically diverse populations.

Methods: Here, we examine the direction, magnitude, and precision of effect sizes for 21 previously reported SNPs from 12 QT loci, in populations of European (n = 16,398), African (n = 5,437), American Indian (n = 5,032), Hispanic (n = 1,143), and Asian (n = 932) descent as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. Estimates obtained from linear regression models stratified by race/ethnicity were combined using inverse-variance weighted meta-analysis. Heterogeneity was evaluated using Cochran's Q test.

Results: Of 21 SNPs, 7 showed consistent direction of effect across all 5 populations, and an additional 9 had estimated effects that were consistent across 4 populations. Despite consistent direction of effect, 9 of 16 SNPs had evidence (P < 0.05) of heterogeneity by race/ethnicity. For these 9 SNPs, linkage disequilibrium plots often indicated substantial variation in linkage disequilibrium patterns among the various racial/ethnic groups, as well as possible allelic heterogeneity.

Conclusions: These results emphasize the importance of analyzing racial/ethnic groups separately in genetic studies. Furthermore, they underscore the possible utility of trans-ethnic studies to pinpoint underlying casual variants influencing heritable traits such as QT.


Publication title











Menzies Institute for Medical Research


Lippincott Williams & Wilkins

Place of publication

530 Walnut St, Philadelphia, USA, Pa, 19106-3621

Rights statement

Copyright 2014 by Lippincott Williams & Wilkins

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified