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Exercise-induced bronchial hyperresponsiveness and parental ISAAC questionnaire responses

journal contribution
posted on 2023-05-16, 10:01 authored by Ponsonby, AL, Couper, DJ, Terry DwyerTerry Dwyer, Carmichael, A, Wood-Baker, R
The predictive value of parental questionnaire responses for exercise-induced bronchoconstriction in childhood asthma has not been fully clarified. The aim of this study was to compare exercise-induced bronchial hyperresponsiveness in 7-year-old children with parental responses to core questions in the International Study of Asthma and Allergies in Childhood (ISAAC) study. A cross-sectional study was conducted on 191 (91% of eligible) children from seven randomly selected schools in Southern Tasmania. Study measurements included a parental questionnaire and exercise challenge testing, using a recently validated 6 min free-running protocol. The response to exercise was assessed using forced expiratory volume in one second (FEV1) measurement. The median percentage fall in FEV1 was significantly higher in children whose parents responded positively to ISAAC questions on a history of wheeze (p = 0.0031) or asthma (p = 0.0005), recent wheeze (p = 0.0005), sleep disturbance due to wheeze (p = 0.0005), or exercise-induced wheeze (p = 0.0015). Receiver operating characteristic (ROC) curve analysis showed exercise-induced bronchial hyperresponsiveness to be a good indicator of current asthma status. Using a 12% or greater fall in FEV1 postexercise as a positive test response, the exercise challenge had sensitivity and specificity estimates for current asthma and exercise-induced wheeze of (0.58 and 0.77) and (0.60 and 0.77), respectively. In conclusion, the respiratory response to exercise was consistent with parental responses to the ISAAC questionnaire in a population-based sample of 7-year-old children. These findings will assist interpretation of large ISAAC studies in terms of asthma prevalence.

History

Publication title

European Respiratory Journal

Volume

9

Issue

7

Pagination

1356-1362

ISSN

0903-1936

Department/School

Menzies Institute for Medical Research

Publisher

European Respiratory Soc Journals Ltd

Place of publication

146 West St, Ste 2.4, Huttons Bldg, Sheffield, England, S1 4Es

Repository Status

  • Restricted

Socio-economic Objectives

Other health not elsewhere classified

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