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Exploring the validity of mild cognitive impairment (MCI) subtypes: Multiple-domain amnestic MCI is the only identifiable subtype at longitudinal follow-up

journal contribution
posted on 2023-05-17, 22:52 authored by Shannon KlekociukShannon Klekociuk, Mathew SummersMathew Summers

Background: Epidemiological research exploring risk factors for Alzheimer’s dementia resulted in the identification of the mild cognitive impairment (MCI) profile. Subsequently, distinct subtypes of MCI have been proposed; however, the validity of these as diagnostic entities remains uncertain.

Design and participants: The aim of the present study was to examine the longitudinal neuropsychological profiles of MCI subtypes. A total of 118 adults aged 60–90 years were classified at screening as amnestic (a-MCI), nonamnestic (na-MCI), and multiple-domain amnestic (a-MCI+) and were assessed at two time points across 20 months on a comprehensive neuropsychological assessment battery.

Results: The a-MCI+ group displayed the poorest performance of all groups in terms of episodic memory, working memory, attention, and executive functioning.

Conclusions: These findings suggest that the a-MCI+ subtype is the only variant that is recognizable via neuropsychological testing. In contrast, the differentiation between single-domain subtypes and healthy controls is difficult and may not be achievable through current neuropsychological assessment practices.


Publication title

Journal of Clinical and Experimental Neuropsychology








Wicking Dementia Research Education Centre


Swets Zeitlinger Publishers

Place of publication

P O Box 825, Lisse, Netherlands, 2160 Sz

Rights statement

Copyright 2014 Taylor & Francis

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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