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Expression of CCR6 on B cells in systemic lupus erythematosus patients

journal contribution
posted on 2023-05-19, 10:18 authored by Adrian Lee, Bannan, JL, Adams, MJ, Heinrich KornerHeinrich Korner
B cells are known to play a dominant pathogenic role in autoimmune conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. In recent times, the chemokine receptor CCR6 and its cognate ligand CCL20 have been shown to play a role in the fundamental kinetics of germinal centres and B cell responses. As CCR6 is found on B cells and is upregulated after activation, we investigated the expression of CCR6 on naive, pre-germinal centre (GC), GC/plasma cell and memory B cells in peripheral B cells of SLE patients and healthy controls using flow cytometry. Pre-germinal centre B cells are found in lower proportions and the expression of CCR6 is increased on B cells of SLE patients, suggesting a role for the chemokine pair in the pathogenesis of the disease. Further studies are needed to explore these preliminary results.

History

Publication title

Clinical Rheumatology

Volume

36

Issue

6

Pagination

1453-1456

ISSN

0770-3198

Department/School

Tasmanian School of Medicine

Publisher

Springer-Verlag

Place of publication

175 Fifth Ave, New York, USA, Ny, 10010

Rights statement

© International League of Associations for Rheumatology (ILAR) 2017

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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