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Extracranial metastases of a glioblastoma multiforme to the pleura, small bowel and pancreas
journal contributionposted on 2023-05-17, 02:30 authored by Mujic, A, Hunn, AWM, Bruce TaylorBruce Taylor, Lowenthal, RM
Extracranial metastases of glioblastoma multiforme (GBM) are rare and usually occur in the context of recurrent intracranial GBM. We present a 39-year-old man with histologically confirmed GBM. The patient remained well for nearly 2 years, with no signs of recurrent tumour. He then presented with distant recurrence within the brain at the same time as developing pneumonia and epigastric pain. A computed tomography scan of the patient's abdomen and chest showed several intra-abdominal masses, including one in the head of the pancreas as well as a separate mass at the base of the left lung. A computed tomography-guided biopsy of the pancreatic mass demonstrated histological appearances identical to those of the original GBM. This unusual case raises the possibility of a link between prolonged survival with GBM and the occurrence of extracranial disease.
Publication titleJournal of Clinical Neuroscience
Department/SchoolMenzies Institute for Medical Research
Place of publication1-3 Baxters Place, Leith Walk, Edinburgh, Scotland, Midlothian, Eh1 3Af