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Factors affecting peak shape in comprehensive two-dimensional gas chromatography with non-focusing modulation

journal contribution
posted on 2023-05-17, 07:53 authored by Harvey, PM, Robert ShellieRobert Shellie
In the case of a non-focusing modulator for comprehensive two-dimensional gas chromatography (GC x GC), the systematic distortions introduced when the modulator loads the second-dimension column give rise to a characteristic peak shape. Depending on the operating conditions this systematic distortion can be the dominant component of the second-dimension elution profiles in the GC x GC peak. The present investigation involved a systematic investigation of peak shape in pulsed-flow modulation (PFM)-GC x GC. It is shown that low flow ratio can lead to significant peak skewing and increasing the flow ratio reduces the magnitude of peak skewing. Validation of the peak shape model is made by comparison with experimental data. The residuals from the fitting process (normalised to the maximum detector response) vary between -1.5% and +2.6% for an isothermal model and between -1.0% and +3.0% for a temperature-programmed model.

Funding

Department of Environment and Energy (Cwth)

History

Publication title

Journal of Chromatography A

Volume

1218

Issue

21

Pagination

3153-3158

ISSN

0021-9673

Department/School

School of Natural Sciences

Publisher

Elsevier Science Bv

Place of publication

PO Box 211, Amsterdam, Netherlands, 1000 Ae

Rights statement

The definitive version is available at http://www.sciencedirect.com

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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