Marine plastic debris has evolved from being a problem to a cross-cutting crisis impacting natural and human environments across the world. Holistic approaches are needed to address the multifaceted, wide-spread and complex nature of this issue. We argue that a new global governance approach is essential, however, it needs to be aligned with interdisciplinary solutions – sound science and data collection; changes to behavioural psychology; utilising education as a tool; and through changes to management and policy processes. We argue that truly effective prevention is a long-term process that must begin at the ground level with smarter consumer choices, industrial consciousness and responsibility, and an overarching local to global governance framework.