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GABAB Receptors Regulate Extrasynaptic GABAA Receptors
journal contribution
posted on 2023-05-20, 02:08 authored by William ConnellyWilliam Connelly, Fyson, SJ, Errington, AC, McCafferty, CP, Cope, DW, Di Giovanni, G, Crunelli, VTonic inhibitory GABAA receptor mediated currents are observed in numerous cell types in the CNS including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells and cerebellar granule cells. Here we show that in rat brain slices activation of postsynaptic GABABreceptors enhances the magnitude of the tonic GABAA current recorded in these cell types via a pathway involving Gi/o G-proteins, adenylate cyclase and cAMP-dependent protein kinase (PKA). Using a combination of pharmacology and knockout mice, we show that this pathway is independent of potassium channels or GABA transporters. Furthermore, the enhancement in tonic current is sufficient to significantly alter the excitability of thalamocortical neurons. These results demonstrate for the first time a postsynaptic cross talk between GABAB and GABAA receptors.
History
Publication title
Journal of NeuroscienceVolume
33Issue
9Pagination
3780-3785ISSN
0270-6474Department/School
Tasmanian School of MedicinePublisher
Soc NeurosciencePlace of publication
11 Dupont Circle, Nw, Ste 500, Washington, USA, Dc, 20036Rights statement
Copyright 2013 the AuthorsRepository Status
- Restricted