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GABAB Receptors Regulate Extrasynaptic GABAA Receptors
journal contributionposted on 2023-05-20, 02:08 authored by William ConnellyWilliam Connelly, Fyson, SJ, Errington, AC, McCafferty, CP, Cope, DW, Di Giovanni, G, Crunelli, V
Tonic inhibitory GABAA receptor mediated currents are observed in numerous cell types in the CNS including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells and cerebellar granule cells. Here we show that in rat brain slices activation of postsynaptic GABABreceptors enhances the magnitude of the tonic GABAA current recorded in these cell types via a pathway involving Gi/o G-proteins, adenylate cyclase and cAMP-dependent protein kinase (PKA). Using a combination of pharmacology and knockout mice, we show that this pathway is independent of potassium channels or GABA transporters. Furthermore, the enhancement in tonic current is sufficient to significantly alter the excitability of thalamocortical neurons. These results demonstrate for the first time a postsynaptic cross talk between GABAB and GABAA receptors.
Publication titleJournal of Neuroscience
Department/SchoolTasmanian School of Medicine
Place of publication11 Dupont Circle, Nw, Ste 500, Washington, USA, Dc, 20036
Rights statementCopyright 2013 the Authors