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GC X GC with Fluidic Modulation for Enantioselective Essential Oil Analysis
journal contributionposted on 2023-05-17, 11:07 authored by Harvey, PMA, Samuel PoynterSamuel Poynter, Robert ShellieRobert Shellie
Properly informed column selection greatly simplifies the process of method development and provides greater flexibility in instrument settings for comprehensive two-dimensional gas chromatography (GC×GC) with fluidic modulation. In the present investigation a long (20 m) narrow-bore (0.10 mm i.d.) column was used in the first separation dimension. In this way, the separation column itself provided sufficient pressure-drop to alleviate flow disturbance in the first dimension column caused by actuating the modulator valve. The use of a narrow-bore column in the first dimension is highly beneficial because it is also more suited to lower volumetric flow-rates and therefore permits use of a longer modulation period without causing sample loop breakthrough. Enantioselective separation of spearmint essential oil was performed to demonstrate performance of a fluidic modulation system.
Publication titleLC-GC Europe (Liquid Chromatography Gas Chromatography)
Department/SchoolSchool of Natural Sciences
Place of publication131 W First St, Duluth, USA, Mn, 55802
Rights statementCopyright 2011 Advanstar Communications Inc.