File(s) under permanent embargo
Genome-Wide Association Study of Prostate Cancer–Specific Survival
BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.
METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).
RESULTS: We observed no significant association between genetic variants and prostate cancer survival.
CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study.
IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.
Publication titleCancer Epidemiology, Biomarkers and Prevention
Department/SchoolMenzies Institute for Medical Research
PublisherAmer Assoc Cancer Research
Place of publicationUnited States
Rights statement© 2015 American Association for Cancer Research