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Genome-Wide Association Study of Prostate Cancer–Specific Survival

journal contribution
posted on 2023-05-18, 14:00 authored by Sulkin, R, Karlsson, R, Whitington, T, Aly, M, Gronberg, H, Eeles, RA, Easton, RA, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, Liesel FitzgeraldLiesel Fitzgerald, Henderson, BE, Schumacher, FR, Haiman, CA, Sipeky, C, Tammela, TL, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharaoh, PD, Pashayan, N, Khaw, KT, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Majer, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Lubinski, J, Kluzniak, W, Cannon--Albright, L, Brenner, H, Herrmann, V, Holleczek, B, Park, JY, Sellers, TA, Lim, HY, Slavov, C, Kaneva, RP, Mitev, VI, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Pandha, H, Michael, A, Kierzek, A, Batra, J, Clements, JA, Andriole, GL, Berndt, SI, Chanock, S, Gapstur, SM, Giovannucci, EL, Hunter, DJ, Kraft, P, Le Marchand, L, Ma, J, Mondul, AM, Penney, KL, Stampfer, MJ, Stevens, VL, Weinstein, SJ, Trichopoulou, A, Bueno-de-Mesquita, BH, Tionneland, A, Cox, DG, Maehle, L, Schleutker, J, Lindstrom, S, Wiklund, F

BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.

METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).

RESULTS: We observed no significant association between genetic variants and prostate cancer survival.

CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study.

IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

History

Publication title

Cancer Epidemiology, Biomarkers and Prevention

Volume

24

Issue

11

Pagination

1796-1800

ISSN

1055-9965

Department/School

Menzies Institute for Medical Research

Publisher

Amer Assoc Cancer Research

Place of publication

United States

Rights statement

© 2015 American Association for Cancer Research

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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    Keywords

    Prostate Cancer GWAS

    Licence

    In Copyright

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