University Of Tasmania

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Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma

journal contribution
posted on 2023-05-19, 19:19 authored by Shiga, Y, Akiyama, M, Nishiguchi, KM, Sato, K, Shimozawa, N, Takahashi, A, Momozawa, Y, Hirata, M, Matsuda, K, Yamaji, T, Iwasaki, M, Tsugane, S, Oze, I, Mikami, H, Naito, M, Wakai, K, Yoshikawa, M, Miyake, M, Yamashiro, K, Kashiwagi, K, Iwata, T, Mabuchi, F, Takamoto, M, Ozaki, M, Kawase, K, Aihara, M, Araie, M, Yamamoto, T, Kiuchi, Y, Nakamura, M, Ikeda, Y, Sonoda, K-H, Ishibashi, T, Nitta, K, Iwase, A, Shirato, S, Oka, Y, Satoh, M, Sasaki, M, Fuse, N, Suzuki, Y, Cheng, C-Y, Khor, CC, Baskaran, M, Perera, S, Aung, T, Vithana, EN, Cooke Bailey, JN, Kang, JH, Pasquale, LR, Haines, JL, Wiggs, JL, Kathryn BurdonKathryn Burdon, Gharahkhani, P, Hewitt, AW, David MackeyDavid Mackey, MacGregor, S, Craig, JE, Allingham, RR, Hauser, M, Ashaye, A, Budenz, DL, Akafo, S, Williams, SEI, Kamatani, Y, Nakazawa, T, Kubo, M
Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 loci have been associated with POAG in Asians. We carried out a genome-wide association study and a replication study that included a total of 7378 POAG cases and 36 385 controls from a Japanese population. After combining the genome-wide association study and the two replication sets, we identified 11 POAG-associated loci, including 4 known (CDKN2B-AS1, ABCA1, SIX6 and AFAP1) and 7 novel loci (FNDC3B, ANKRD55-MAP3K1, LMX1B, LHPP, HMGA2, MEIS2 and LOXL1) at a genome-wide significance level (P < 5.0×10-8), bringing the total number of POAG-susceptibility loci to 22. The 7 novel variants were subsequently evaluated in a multiethnic population comprising non-Japanese East Asians (1008 cases, 591 controls), Europeans (5008 cases, 35 472 controls) and Africans (2341 cases, 2037 controls). The candidate genes located within the new loci were related to ocular development (LMX1B, HMGA2 and MAP3K1) and glaucoma-related phenotypes (FNDC3B, LMX1B and LOXL1). Pathway analysis suggested epidermal growth factor receptor signaling might be involved in POAG pathogenesis. Genetic correlation analysis revealed the relationships between POAG and systemic diseases, including type 2 diabetes and cardiovascular diseases. These results improve our understanding of the genetic factors that affect the risk of developing POAG and provide new insight into the genetic architecture of POAG in Asians.


National Health & Medical Research Council


Publication title

Human Molecular Genetics










Menzies Institute for Medical Research


Oxford Univ Press

Place of publication

Great Clarendon St, Oxford, England, Ox2 6Dp

Rights statement

Copyright 2018 The Authors

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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