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Hardwiring the bain: Endocannabinoids shape neuronal connectivity

journal contribution
posted on 2023-05-17, 06:15 authored by Berghuis, P, Rajnicek, AM, Morozov, YM, Ross, RA, Mulder, J, Urban, GM, Monory, K, Marsicano, G, Matteoli, M, Alison CantyAlison Canty, Irving, AJ, Katona, I, Yanagawa, Y, Rakic, P, Lutz, B, Mackie, K, Harkany, T
The roles of endocannabinoid signaling during central nervous system development are unknown. We report that CB(1) cannabinoid receptors (CB(1)Rs) are enriched in the axonal growth cones of gamma-aminobutyric acid-containing (GABAergic) interneurons in the rodent cortex during late gestation. Endocannabinoids trigger CB(1)R internalization and elimination from filopodia and induce chemorepulsion and collapse of axonal growth cones of these GABAergic interneurons by activating RhoA. Similarly, endocannabinoids diminish the galvanotropism of Xenopus laevis spinal neurons. These findings, together with the impaired target selection of cortical GABAergic interneurons lacking CB(1)Rs, identify endocannabinoids as axon guidance cues and demonstrate that endocannabinoid signaling regulates synaptogenesis and target selection in vivo.

History

Publication title

Science

Volume

316

Issue

5828

Pagination

1212-1216

ISSN

0036-8075

Department/School

Tasmanian School of Medicine

Publisher

Amer Assoc Advancement Science

Place of publication

1200 New York Ave, Nw, Washington, USA, Dc, 20005

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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