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Health economic consequences of the use of irbesartan in patients with type 2 diabetes, hypertension and nephropathy in Switzerland
journal contributionposted on 2023-05-17, 09:28 authored by Frei, A, Palmer, AJ, Burnier, M, Hess, B
The irbesartan in Diabetic Nephropathy Trial (IDNT) demonstrated that treatment of patients with type 2 diabetes, hypertension and nephropathy with irbesartan resulted in a 20% relative reduction of the composite endpoint of doubling serum creatinine, end-stage renal disease or death as compared with amlodipine and placebo (antihypertensive standard therapy). The objective of this study was to investigate the long-term health economic consequences of this treatment strategy in a Swiss health care setting. This analysis used a Markov model to simulate the progression of nephropathy, life-years and treatment costs over ten years for each of the three treatment options. In additon, sensitivity analyses were performed. Treatment with irbesartan will save CHF 22 681/patient as compared with amlodipine and CHF 13 847 as compared with standard therapy. Â© 2006 by Verlag Hans Huber, Hogrefe AG.
Publication titlePraxis: Schweizerische Rundschau fuer Medizin
PublisherVerlag Hans Huber AG
Place of publicationSwitzerland