Heat shock proteins as an aid in the treatment and diagnosis of heat stroke

It is now well established that induction of heat shock protein 72 (HSP72) protects the cell or tissue against a second otherwise lethal exposure to heat, a phenomenon known as thermotolerance. Because of this protective role, HSP72 is potentially useful in the treatment of heat illnesses, which range from relatively benign disorders such as heat cramps to heat stroke, which can be life threatening. This review discusses various ways in which HSP72 might be used in the diagnosis and treatment of the heat illnesses. This includes methods to induce HSP72, analysis of HSP72 in the cells and tissues of heat stroke patients, and screening methods to detect individuals who may be heat intolerant. Crown Copyright © 2008.