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High-throughput gas chromatography for volatile compounds analysis by fast temperature programming and adsorption chromatography

journal contribution
posted on 2023-05-19, 07:13 authored by Gras, R, Hua, Y, Luong, J
The synergy of combining fast temperature programming capability and adsorption chromatography using fused silica based porous layer open tubular columns to achieve high throughput chromatography for the separation of volatile compounds is presented. A gas chromatograph with built-in fast temperature programming capability and having a fast cool down rate was used as a platform. When these performance features were combined with the high degree of selectivity and strong retention characteristic of porous layer open tubular column technology, volatile compounds such as light hydrocarbons of up to C7, primary alcohols, and mercaptans can be well separated and analyzed in a matter of minutes. This analytical approach substantially improves sample throughput by at least a factor of ten times when compared to published methodologies. In addition, the use of porous layer open tubular columns advantageously eliminates the need for costly and time-consuming cryogenic gas chromatography required for the separation of highly volatile compounds by partition chromatography with wall coated open tubular column technology. Relative standard deviations of retention time for model compounds such as alkanes from methane to hexane were found to be less than 0.3% (n = 10) and less than 0.5% for area counts for the compounds tested at two levels of concentration by manual injection, namely, 10 and 1000 ppm v/v (n = 10). Difficult separations were accomplished in one single analysis in less than 2 min such as the characterization of 17 components in cracked gas containing alkanes, alkenes, dienes, branched hydrocarbons, and cyclic hydrocarbons.

History

Publication title

Journal of Separation Science

Volume

40

Issue

9

Pagination

1979-1984

ISSN

1615-9306

Department/School

School of Natural Sciences

Publisher

Wiley - V C H Verlag GmbH & Co. KGaA

Place of publication

Postfach 101161 Weinheim, 69451 Germany

Rights statement

Copyright 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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