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Higher maternal body mass index is associated with an increased risk for later type 2 diabetes in offspring

journal contribution
posted on 2023-05-17, 15:43 authored by Juonala, M, Jaaskelainen, P, Sabin, MA, Viikari, JSA, Kahonen, M, Lehtimaki, T, Seppala, I, Hutri-Kahonen, N, Taittonen, L, Jokinen, E, Laitinen, T, Costan MagnussenCostan Magnussen, Raitakari, OT

Objectives: To investigate whether the body mass index (BMI) of a child's mother is associated with an increased future risk of type 2 diabetes, independent of genetic risk or childhood metabolic, behavioral, and environmental factors.

Study design: The analyses were based on the Cardiovascular Risk in Young Finns Study including 1835 individuals aged 3-18 years at baseline with data on maternal BMI, childhood metabolic factors, as well as 34 newly identified type 2 diabetes susceptibility alleles. These subjects were then followed-up over 21-27 years.

Results: Maternal BMI (OR for 1-SD increase 1.54 [95% CI 1.12-2.11], P = .008) and child's systolic blood pressure (1.54 [1.01-2.35], P = .04) were significantly associated with increased odds for later type 2 diabetes, in a multivariable analysis adjusted for age, sex, type 2 diabetes genetic risk score, childhood BMI, insulin, lipids, dietary factors, socioeconomic status, and mother's age, and history of type 2 diabetes. A risk prediction model, which included maternal BMI status outperformed one which utilized only child's BMI data (area under the receiver operating characteristic curve 0.720 vs 0.623, P = .02). The inclusion of genetic risk score and other baseline risk variables did not additionally improve prediction (area under the receiver operating characteristic curve 0.720 vs 0.745, P = .40).

Conclusions: Maternal BMI is a useful variable in determining offspring risk of developing type 2 diabetes.


Publication title

Journal of Pediatrics










Menzies Institute for Medical Research


Mosby, Inc

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Copyright 2013 Mosby.

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