University Of Tasmania
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Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

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journal contribution
posted on 2023-05-19, 20:27 authored by Karch, CM, Hernandez, D, Wang, J-C, Marsh, J, Alexander HewittAlexander Hewitt, Hsu, S, Norton, J, Levitch, D, Donahue, T, Sigurdson, W, Ghetti, B, Farlow, M, Chhatwal, J, Berman, S, Cruchaga, C, Morris, JC, Bateman, RJ, Pebay, A, Goate, AM
Background: Mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) cause autosomal dominant forms of Alzheimer disease (ADAD). More than 280 pathogenic mutations have been reported in APP, PSEN1, and PSEN2. However, understanding of the basic biological mechanisms that drive the disease are limited. The Dominantly Inherited Alzheimer Network (DIAN) is an international observational study of APP, PSEN1, and PSEN2 mutation carriers with the goal of determining the sequence of changes in presymptomatic mutation carriers who are destined to develop Alzheimer disease.

Results: We generated a library of 98 dermal fibroblast lines from 42 ADAD families enrolled in DIAN. We have reprogrammed a subset of the DIAN fibroblast lines into patient-specific induced pluripotent stem cell (iPSC) lines. These cells were thoroughly characterized for pluripotency markers.

Conclusions: This library represents a comprehensive resource that can be used for disease modeling and the development of novel therapeutics.


Publication title

Alzheimer's Research and Therapy



Article number









Menzies Institute for Medical Research


BioMed Central Ltd.

Place of publication

United Kingdom

Rights statement

© 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified